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Image Search Results
Journal: Frontiers in Immunology
Article Title: Sulfotransferase SULT2B1 contributes to the epithelial–immune microenvironment homeostasis in imiquimod-induced psoriatic dermatitis
doi: 10.3389/fimmu.2025.1632426
Figure Lengend Snippet: T-helper (Th)-1 cytokines promote SULT2B1 mRNA expression in human keratinocytes. (A) Epidermal CS levels in healthy controls (n = 30) and patients with the indicated skin diseases [seborrheic keratoses (n = 9), actinic keratoses (n = 10), tinea corporis (n = 3), atopic dermatitis (non-lesional, n = 9; lesional, n = 10), and psoriasis (non-lesional: n = 16; lesional: n = 37)] quantified via supercritical fluid chromatography-tandem mass spectrometry (SFC-MS/MS; one-way ANOVA, followed by Dunnett’s multiple-comparison test). (B, C) Real-time PCR analysis of SULT2B1 gene levels in undifferentiated (B) or differentiated (C) normal human epidermal keratinocytes (NHEKs) treated with two concentrations of the indicated cytokines (n = 6/group; one-way ANOVA, followed by Dunnett’s multiple-comparison test). Data were obtained from six (B, C) independent experiments, and graphs are represented as the mean ± SD. ** P < 0.01 and *** P < 0.001; ns, not significant.
Article Snippet:
Techniques: Expressing, Supercritical Fluid Chromatography, Mass Spectrometry, Tandem Mass Spectroscopy, Comparison, Real-time Polymerase Chain Reaction